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Article

Effects of Metformin on the virus/host cell crosstalk in human papillomavirus‐positive cancer cells

12 Apr 2021

Abstract excerpt

Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The viral E6/E7 oncogenes maintain the malignant growth of HPV-positive cancer cells. Targeted E6/E7 inhibition results in efficient induction of cellular senescence, which could be exploited for therapeutic purposes. Here we show that viral E6/E7 expression is strongly downregulated by Metformin in HPV-positive cervical cancer and head...

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PMID: 33844847
DOI: 10.1002/ijc.33594

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