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Article

Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen.

The Journal of infectious diseases - 15 Jul 2017

Bei Amy K, Ahouidi Ambroise D, Dvorin Jeffrey D, Miura Kazutoyo, Diouf Ababacar, Ndiaye Daouda, Premji Zul, Diakite Mahamadou, Mboup Souleymane, Long Carole A, Duraisingh Manoj T

Abstract excerpt

Background: Plasmodium falciparum reticulocyte-binding protein homologue 2b (PfRh2b) is an invasion ligand that is a potential blood-stage vaccine candidate antigen; however, a naturally occurring deletion within an immunogenic domain is present at high frequencies in Africa and has been associated with alternative invasion pathway usage. Standardized tools that provide antigenic specificity in in vitro assays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28605544
DOI: 10.1093/infdis/jix280
PMCID: PMC5853457

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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