Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessing the functional impact of PfRh5 genetic diversity on ex vivo erythrocyte invasion inhibition.

Scientific reports - 26 Jan 2021

Moore Adam J, Mangou Khadidiatou, Diallo Fatoumata, Sene Seynabou D, Pouye Mariama N, Sadio Bacary D, Faye Ousmane, Mbengue Alassane, Bei Amy K

Abstract excerpt

The PfRh5-Basigin ligand-receptor interaction is an essential step in the merozoite invasion process and represents an attractive vaccine target. To reveal genotype-phenotype associations between naturally occurring allelic variants of PfRh5 and invasion inhibition, we performed ex vivo invasion inhibition assays with monoclonal antibodies targeting basigin coupled with PfRh5 next-generation amplicon sequencing....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocytes

Share to High-Throughput Nucleotide Sequencing

Share to Plasmodium falciparum

Share to Polymorphism, Single Nucleotide

Share to Protozoan Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33500482
DOI: 10.1038/s41598-021-81711-9
PMCID: PMC7838290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing the functional impact of PfRh5 genetic diversity on ex vivo erythrocyte invasion inhibition.PMID 33500482Read ↗

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants.Semantic proximity Read ↗

Basigin is a druggable target for host-oriented antimalarial interventionsSemantic proximity Read ↗

Erythrocyte Binding Protein PfRH5 Polymorphisms Determine Species-Specific Pathways of Plasmodium falciparum InvasionSemantic proximity Read ↗

Extent and Dynamics of Polymorphism in the Malaria Vaccine Candidate Plasmodium falciparum Reticulocyte–Binding Protein Homologue-5 in Kalifabougou, MaliSemantic proximity Read ↗

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPASemantic proximity Read ↗

Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for <i>Plasmodium falciparum</i> erythrocyte invasionSemantic proximity Read ↗

Host–parasite interactions that guide red blood cell invasion by malaria parasitesSemantic proximity Read ↗

Estimation of PfRh5-based vaccine efficacy in asymptomatic Plasmodium falciparum patients from high-endemic areas of Tanzania using genetic and antigenicity variation screening.Semantic proximity Read ↗

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody ClonotypeSemantic proximity Read ↗

Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN).Semantic proximity Read ↗

Associations between defined polymorphic variants in the PfRH ligand family and the invasion pathways used by P. falciparum field isolates from Brazil.Semantic proximity Read ↗

Invasion by P. falciparum Merozoites Suggests a Hierarchy of Molecular InteractionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.