Article
The diversity of O-linked glycans expressed during Drosophila melanogaster development reflects stage- and tissue-specific requirements for cell signaling.
The Journal of biological chemistry - 31 Oct 2008
Aoki Kazuhiro, Porterfield Mindy, Lee Samuel S, Dong Brian, Nguyen Khoi, McGlamry Katherine H, Tiemeyer Michael
Abstract excerpt
Appropriate glycoprotein O-glycosylation is essential for normal development and tissue function in multicellular organisms. To comprehensively assess the developmental and functional impact of altered O-glycosylation, we have extensively analyzed the non-glycosaminoglycan, O-linked glycans expressed in Drosophila embryos. Through multidimensional mass spectrometric analysis of glycans released from glycoproteins...
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