Structure of the ACF7 EF-Hand-GAR Module and Delineation of Microtubule Binding Determinants.

Abstract excerpt

Spectraplakins are large molecules that cross-link F-actin and microtubules (MTs). Mutations in spectraplakins yield defective cell polarization, aberrant focal adhesion dynamics, and dystonia. We present the 2.8 Å crystal structure of the hACF7 EF1-EF2-GAR MT-binding module and delineate the GAR residues critical for MT binding. The EF1-EF2 and GAR domains are autonomous domains connected by a flexible linker....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to EF Hand Motifs
• Share to HEK293 Cells