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Article

Interaction of Filamin C With Actin Is Essential for Cardiac Development and Function.

Circulation research - 18 Aug 2023

Zhou Xiaohai, Fang Xi, Ithychanda Sujay Subbayya, Wu Tongbin, Gu Yusu, Chen Chao, Wang Li, Bogomolovas Julius, Qin Jun, Chen Ju

Abstract excerpt

BACKGROUND: FLNC (filamin C), a member of the filamin family predominantly expressed in striated muscles, plays a crucial role in bridging the cytoskeleton and ECM (extracellular matrix) in cardiomyocytes, thereby maintaining heart integrity and function. Although genetic variants within the N-terminal ABD (actin-binding domain) of FLNC have been identified in patients with cardiomyopathy, the precise...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37492967
DOI: 10.1161/CIRCRESAHA.123.322750
PMCID: PMC10529502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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