Article
Sequence variant at 4q25 near PITX2 associates with appendicitis.
Scientific reports - 8 Jun 2017
Kristjansson Ragnar P, Benonisdottir Stefania, Oddsson Asmundur, Galesloot Tessel E, Thorleifsson Gudmar, Aben Katja K, Davidsson Olafur B, Jonsson Stefan, Arnadottir Gudny A, Jensson Brynjar O, Walters G Bragi, Sigurdsson Jon K, Sigurdsson Snaevar, Holm Hilma, Arnar David O, Thorgeirsson Gudmundur, Alexiusdottir Kristin, Jonsdottir Ingileif, Thorsteinsdottir Unnur, Kiemeney Lambertus A, Jonsson Thorvaldur, Gudbjartsson Daniel F, Rafnar Thorunn, Sulem Patrick, Stefansson Kari
Abstract excerpt
Appendicitis is one of the most common conditions requiring acute surgery and can pose a threat to the lives of affected individuals. We performed a genome-wide association study of appendicitis in 7,276 Icelandic and 1,139 Dutch cases and large groups of controls. In a combined analysis of the Icelandic and Dutch data, we detected a single signal represented by an intergenic variant rs2129979 [G] close to the...
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