Article
Genetic association and differential expression of PITX2 with acute appendicitis.
Human genetics - 1 Jan 2019
Orlova Ekaterina, Yeh Andrew, Shi Min, Firek Brian, Ranganathan Sarangarajan, Whitcomb David C, Finegold David N, Ferrell Robert E, Barmada M Michael, Marazita Mary L, Hinds David A, Shaffer John R, Morowitz Michael J
Abstract excerpt
Appendicitis affects 9% of Americans and is the most common diagnosis requiring hospitalization of both children and adults. We performed a genome-wide association study of self-reported appendectomy with 18,773 affected adults and 114,907 unaffected adults of European American ancestry. A significant association with appendectomy was observed at 4q25 near the gene PITX2 (rs2129979, p value = 8.82 × 10-14) and...
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