Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.

doi:10.1038/ncomms15789

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Article

Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.

Nature communications - 6 Jun 2017

Sigurdsson Snaevar, Alexandersson Kristjan F, Sulem Patrick, Feenstra Bjarke, Gudmundsdottir Steinunn, Halldorsson Gisli H, Olafsson Sigurgeir, Sigurdsson Asgeir, Rafnar Thorunn, Thorgeirsson Thorgeir, Sørensen Erik, Nordholm-Carstensen Andreas, Burcharth Jakob, Andersen Jens, Jørgensen Henrik Stig, Possfelt-Møller Emma, Ullum Henrik, Thorleifsson Gudmar, Masson Gisli, Thorsteinsdottir Unnur, Melbye Mads, Gudbjartsson Daniel F, Stefansson Tryggvi, Jonsdottir Ingileif, Stefansson Kari

Abstract excerpt

Diverticular disease is characterized by pouches (that is, diverticulae) due to weakness in the bowel wall, which can become infected and inflamed causing diverticulitis, with potentially severe complications. Here, we test 32.4 million sequence variants identified through whole-genome sequencing (WGS) of 15,220 Icelanders for association with diverticular disease (5,426 cases) and its more severe form...

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Identifiers

PMID: 28585551
DOI: 10.1038/ncomms15789
PMCID: PMC5467205

Genes

ARHGAP15
COLQ

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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