Article
SEPTIN7 Deficiency Disrupts Endothelial Integrity and Causes Myxomatous Valve Disease in Juvenile Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2026
Fang Yuan, Su Hongyu, Dong Jinling, Xue Weihao, Yan Chengrong, Ma Shaozhou, Yang Lihua, Min Xin, Qian Benheng, Lai Baochang, Xi Rui, Zhang Donghong, Zhang Yanmin, Zhou Bin, Shi Lei, Wu Lianpin, Xiao Feng, Wang Yidong
Abstract excerpt
BACKGROUND: Myxomatous valve degeneration is a major contributor to adult-onset valvular disease, with congenital valve abnormalities being a predisposing factor. However, the molecular networks that govern heart valve development, particularly postnatal valve maturation, remain poorly understood. This study was designed to investigate the role of GTP‑binding SEPTIN proteins in heart valve formation. METHODS: We...
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- Animals
- Septins
- Cell Proliferation
- Mice, Knockout
- Phenotype