Article
The Beavis Effect in Next-Generation Mapping Panels in Drosophila melanogaster.
G3 (Bethesda, Md.) - 7 Jun 2017
King Elizabeth G, Long Anthony D
Abstract excerpt
A major goal in the analysis of complex traits is to partition the observed genetic variation in a trait into components due to individual loci and perhaps variants within those loci. However, in both QTL mapping and genetic association studies, the estimated percent variation attributable to a QTL is upwardly biased conditional on it being discovered. This bias was first described in two-way QTL mapping...
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