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Article

The illusion of polygenicity in pool-seq genetic mapping studies: insufficient power can mask simple genetic architectures.

Genetics - 6 May 2026

Long Anthony D, Hanson Katherine M, Macdonald Stuart J

Abstract excerpt

Pool-seq (pooled sequencing) combines DNA from multiple individuals prior to sequencing, enabling population-level allele frequency estimation without individual genotyping. When employed in a case-control genome-wide association study (GWAS) framework, pool-seq faces a fundamental power limitation: Errors on allele frequency estimates are inversely proportional to sequence coverage and are large at modest...

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PMID: 41812229
DOI: 10.1093/genetics/iyag068
PMCID: PMC13147526

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