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Target Enrichment Improves Mapping of Complex Traits by Deep Sequencing.

G3 (Bethesda, Md.) - 3 Nov 2015

Guo Jianjun, Fan Jue, Hauser Bernard A, Rhee Seung Y

Abstract excerpt

Complex traits such as crop performance and human diseases are controlled by multiple genetic loci, many of which have small effects and often go undetected by traditional quantitative trait locus (QTL) mapping. Recently, bulked segregant analysis with large F2 pools and genome-level markers (named extreme-QTL or X-QTL mapping) has been used to identify many QTL. To estimate parameters impacting QTL detection for...

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PMID: 26530422
DOI: 10.1534/g3.115.023671
PMCID: PMC4704726

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