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Article

Bifurcated BACH2 control coordinates mantle cell lymphoma survival and dispersal during hypoxia

7 Jun 2017

Abstract excerpt

BACH2, a B-cell-specific transcription factor, plays a critical role in oxidative stress-mediated drug resistance in mantle cell lymphoma (MCL); however, the biological functions of BACH2 and its regulation of B-cell malignancies in chronic hypoxic microenvironment have not been studied. Here, we found that silencing BACH2 led to not only increased tumor formation and colony formation but also increased tumor...

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PMID: 28592433
DOI: 10.1182/blood-2017-02-767293

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