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Article

BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53

21 Dec 2016

Abstract excerpt

The acquisition of drug resistance is a persistent clinical problem limiting the successful treatment of glioblastoma (GBM). However, the molecular mechanisms by which initially chemoresponsive tumors develop therapeutic resistance remain poorly understood. In this study, we report that BACH1, a heme-binding protein that participates in transcriptional repression or activation, was significantly upregulated in...

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PMID: 28000777
DOI: 10.1038/srep39743

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BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53PMID 28000777Read ↗

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