Cross‐altitude analysis suggests a turning point at the elevation of 4,500 m for polycythemia prevalence in Tibetans

Abstract excerpt

Tibetans are a well-known example of genetic adaptation to hypoxic environments at high altitude.1 Both genetic and archeological data suggest that Tibetans have been living at the Qinghai-Tibetan plateau since late Paleolithic time (as early as ∼30,000 years ago).2, 3 Due to long-time natural selection, Tibetans have accumulated many adaptive mutations in the hypoxia-related genes (e.g., EPAS1 and EGLN1),4-8...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Climate Change and Health Impacts
• Share to High Altitude and Hypoxia
• Share to Liver Disease Diagnosis and Treatment