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Article

A novel network regularized matrix decomposition method to detect mutated cancer genes in tumour samples with inter-patient heterogeneity.

Scientific reports - 6 Jun 2017

Xi Jianing, Li Ao, Wang Minghui

Abstract excerpt

Inter-patient heterogeneity is a major challenge for mutated cancer genes detection which is crucial to advance cancer diagnostics and therapeutics. To detect mutated cancer genes in heterogeneous tumour samples, a prominent strategy is to determine whether the genes are recurrently mutated in their interaction network context. However, recent studies show that some cancer genes in different perturbed pathways...

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PMID: 28588243
DOI: 10.1038/s41598-017-03141-w
PMCID: PMC5460199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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