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Article

Detecting recurrent gene mutation in interaction network context using multi-scale graph diffusion.

BMC bioinformatics - 23 Jan 2013

Babaei Sepideh, Hulsman Marc, Reinders Marcel, de Ridder Jeroen

Abstract excerpt

BACKGROUND: Delineating the molecular drivers of cancer, i.e. determining cancer genes and the pathways which they deregulate, is an important challenge in cancer research. In this study, we aim to identify pathways of frequently mutated genes by exploiting their network neighborhood encoded in the protein-protein interaction network. To this end, we introduce a multi-scale diffusion kernel and apply it to a...

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Identifiers

PMID: 23343428
DOI: 10.1186/1471-2105-14-29
PMCID: PMC3626877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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