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Article

Network based stratification of major cancers by integrating somatic mutation and gene expression data.

PloS one - 1 Jan 2017

He Zongzhen, Zhang Junying, Yuan Xiguo, Liu Zhaowen, Liu Baobao, Tuo Shouheng, Liu Yajun

Abstract excerpt

The stratification of cancer into subtypes that are significantly associated with clinical outcomes is beneficial for targeted prognosis and treatment. In this study, we integrated somatic mutation and gene expression data to identify clusters of patients. In contrast to previous studies, we constructed cancer-type-specific significant co-expression networks (SCNs) rather than using a fixed gene network across...

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Identifiers

PMID: 28520777
DOI: 10.1371/journal.pone.0177662
PMCID: PMC5433734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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