Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Production of transgenic pig as an Alzheimer's disease model using a multi-cistronic vector system.

PloS one - 1 Jan 2017

Lee Seung-Eun, Hyun Hyuk, Park Mi-Ryung, Choi Youngsok, Son Yeo-Jin, Park Yun-Gwi, Jeong Sang-Gi, Shin Min-Young, Ha Hee-Jin, Hong Hyun-Sok, Choi Min-Keyung, Im Gi-Sun, Park Eung-Woo, Kim Young-Ho, Park Chankyu, Kim Eun-Young, Park Se-Pill

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with memory loss and cognitive impairments. An AD transgenic (Tg) pig model would be useful for preclinical testing of therapeutic agents. We generated an AD Tg pig by somatic cell nuclear transfer (SCNT) using a multi-cistronic vector that harbored three AD-related genes with a total of six well-characterized mutations: hAPP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Swine
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Animals, Genetically Modified

Share to Blastocyst

Share to Fibroblasts

Share to Genetic Vectors

Share to Nuclear Transfer Techniques

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 28586343
DOI: 10.1371/journal.pone.0177933
PMCID: PMC5460854

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Production of transgenic pig as an Alzheimer's disease model using a multi-cistronic vector system.PMID 28586343Read ↗

Expression of the Alzheimer's Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs.Semantic proximity Read ↗

Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw.Semantic proximity Read ↗

Multi‑transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis.Semantic proximity Read ↗

A canine model of Alzheimer's disease generated by overexpressing a mutated human amyloid precursor protein.Semantic proximity Read ↗

Use of the 2A Peptide for Generation of Multi-Transgenic Pigs through a Single Round of Nuclear TransferSemantic proximity Read ↗

Generation of gene-targeted mice using embryonic stem cells derived from a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Establishment of induced pluripotent stem cell line (ZZUi010-A) from an Alzheimer's disease patient carrying an APP gene mutation.Semantic proximity Read ↗

A Transgenic Pig Model With Human Mutant SOD1 Exhibits the Early Pathology of Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Impaired Skeletal Development by Disruption of Presenilin-1 in Pigs and Generation of Novel Pig Models for Alzheimer's Disease.Semantic proximity Read ↗

Multi-transgenic pigs expressing three fluorescent proteins produced with high efficiency by sperm mediated gene transferSemantic proximity Read ↗

Virus-Mediated Gene Transfer of Soluble Amyloid Precursor Protein-alpha via Systemic Injection in a Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

Porcine APP cDNAs: molecular cloning and characterization, expression analysis, chromosomal localization and SNP analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.