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Multi-transgenic pigs expressing three fluorescent proteins produced with high efficiency by sperm mediated gene transfer

1 Jan 2005

Abstract excerpt

Multi-gene transgenic pigs would be of benefit for large animal models in medical, agricultural, and pharmaceutical applications; in particular for xenotransplantation, where extensive genetic manipulation of donor pigs is required to make them suitable for organ grafting to humans. We used the sperm mediated gene transfer (SMGT) method to produce with high efficiency multi-gene transgenic pigs using three genes...

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PMID: 15906394
DOI: 10.1002/mrd.20316

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