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Article

Multi‑transgenic minipig models exhibiting potential for hepatic insulin resistance and pancreatic apoptosis.

Molecular medicine reports - 1 Jan 2016

Kong Siyuan, Ruan Jinxue, Xin Leilei, Fan Junhua, Xia Jihan, Liu Zhiguo, Mu Yulian, Yang Shulin, Li Kui

Abstract excerpt

There are currently no multi‑transgenic minipig models of diabetes for the regulation of multiple genes involved in its pathogenesis. The foot and mouth disease virus 2A (F2A)‑mediated polycistronic system possesses several advantages, and the present study developed a novel multi‑transgenic minipig model associated with diabetes using this system. The tissue‑specific polycistronic system used in the present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26648014
DOI: 10.3892/mmr.2015.4582
PMCID: PMC4686100

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EBP

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