Article

Rho GTPase Activating Protein 15 (ARHGAP15) increases cancer risk in patients with diverticular disease

2022-11-01

Abstract excerpt

<h4>Introduction</h4> Patients with diverticular disease who have colorectal histopathology, normal or abnormal, have increased risk of overall incident cancer. To determine whether the cancer risk might have a genetic basis, we performed a Genome Wide Association Study (GWAS) with data from UK Biobank. <h4>Methods</h4> We used PLINK 2, a whole-genome association analysis toolset, to analyze the UKB chromosome fil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df7d2cdd-79e7-56fd-925a-c3895d111d5e
DOI: 10.1101/2022.10.30.22281714

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rho GTPase Activating Protein 15 (ARHGAP15) increases cancer risk in patients with diverticular diseaseDOI 10.1101/2022.10.30.22281714Read

Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.Semantic proximity Read

Genetic, epigenetic and environmental factors in diverticular disease: systematic review.Semantic proximity Read

Common variation in FAM155A is associated with diverticulitis but not diverticulosis.Semantic proximity Read

Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.Semantic proximity Read

COLQ and ARHGAP15 are Associated with Diverticular Disease and are Expressed in the Colon.Semantic proximity Read

Diverticulitis and Crohn's disease have distinct but overlapping tumor necrosis superfamily 15 haplotypes.Semantic proximity Read

150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibilitySemantic proximity Read

RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitisSemantic proximity Read

Diverticular disease genome-wide association meta-analysis identifies 257 novel loci, implicates structure and motilitySemantic proximity Read

Collagen (rs3134646) and ARHGAP15 (rs4662344) genetic variants may predispose to colonic diverticulosisSemantic proximity Read

Genetic Risk, Healthy Lifestyle, and Risk Stratification for Diverticulitis.Semantic proximity Read

A Multi-Omics Analysis of the Prognostic Biomarker GDF15 Associated with Immune Infiltration and Regulated Mitochondrial-Dependent Apoptosis in Colorectal CancerSemantic proximity Read