Article
The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing.
Nature communications - 5 Jun 2017
Ye Lei, Zhou Xiaoyi, Huang Fengjiao, Wang Weixi, Qi Yicheng, Xu Heng, Yang Shu, Shen Liyun, Fei Xiaochun, Xie Jing, Cao Min, Zhou Yulin, Zhu Wei, Wang Shu, Ning Guang, Wang Weiqing
Abstract excerpt
The genomic alterations for benign thyroid nodule, especially adenomatoid nodule, one of the most common types of hyperplasia lesion, are ill-studied. Here, we show whole-exome sequencing and/or transcriptome sequencing data on adenomatoid nodules with or without coincidental papillary thyroid carcinoma (PTC). Somatic mutation of BRAF (22/32) is only detected in PTC, while mutations in SPOP (4/38), ZNF148 (6/38)...
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