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Article

CLEC5A Regulates Japanese Encephalitis Virus-Induced Neuroinflammation and Lethality

19 Apr 2012

Abstract excerpt

CLEC5A/MDL-1, a member of the myeloid C-type lectin family expressed on macrophages and neutrophils, is critical for dengue virus (DV)-induced hemorrhagic fever and shock syndrome in Stat1⁻/⁻ mice and ConA-treated wild type mice. However, whether CLEC5A is involved in the pathogenesis of viral encephalitis has not yet been investigated. To investigate the role of CLEC5A to regulate JEV-induced neuroinflammation,...

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PMID: 22536153
DOI: 10.1371/journal.ppat.1002655

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