Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease.

American journal of human genetics - 1 Jun 2017

Ko Yi-An, Yi Huiguang, Qiu Chengxiang, Huang Shizheng, Park Jihwan, Ledo Nora, Köttgen Anna, Li Hongzhe, Rader Daniel J, Pack Michael A, Brown Christopher D, Susztak Katalin

Abstract excerpt

Chronic kidney disease (CKD) is a complex gene-environmental disease affecting close to 10% of the US population. Genome-wide association studies (GWASs) have identified sequence variants, localized to non-coding genomic regions, associated with kidney function. Despite these robust observations, the mechanism by which variants lead to CKD remains a critical unanswered question. Expression quantitative trait loci...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Knockdown Techniques
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney

Share to Kidney Diseases

Share to Linkage Disequilibrium

Share to Quantitative Trait, Heritable

Share to Reproducibility of Results

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 28575649
DOI: 10.1016/j.ajhg.2017.05.004
PMCID: PMC5473735

Genes

MANBA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease.PMID 28575649Read ↗

Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease.Semantic proximity Read ↗

Functional Genomic Annotation of Genetic Risk Loci Highlights Inflammation and Epithelial Biology Networks in CKDSemantic proximity Read ↗

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms.Semantic proximity Read ↗

Kidney disease genetic risk variants alter lysosomal beta-mannosidase ( MANBA ) expression and disease severitySemantic proximity Read ↗

A catalog of genetic loci associated with kidney function from analyses of a million individualsSemantic proximity Read ↗

Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.Semantic proximity Read ↗

Integrative kidney multi-omics traces genetic drivers of chronic kidney disease to targets within the renal epigenome, transcriptome and proteomeSemantic proximity Read ↗

Multi-Omic Analysis Reveals Genetic Determinants and Therapeutic Targets of Chronic Kidney Disease and Kidney Function.Semantic proximity Read ↗

Molecular insights into genome-wide association studies of chronic kidney disease-defining traitsSemantic proximity Read ↗

Human Kidney Alternative Splicing Information Illuminates Cardiovascular-Kidney-Metabolic Syndrome RiskSemantic proximity Read ↗

Chromatin architecture reveals cell type-specific target genes for kidney disease risk variantsSemantic proximity Read ↗

Genome-Wide Association Studies of CKD and Related Traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.