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Article

Activating Calcium-Sensing Receptor Mutations: Prospects for Future Treatment with Calcilytics.

Trends in endocrinology and metabolism: TEM - 1 Sept 2016

Mayr Bernhard, Glaudo Markus, Schöfl Christof

Abstract excerpt

Activating mutations of the G protein-coupled receptor, calcium-sensing receptor (CaSR), cause autosomal dominant hypocalcemia and Bartter syndrome type 5. These mutations lower the set-point for extracellular calcium sensing, thereby causing decreased parathyroid hormone secretion and disturbed renal calcium handling with hypercalciuria. Available therapies increase serum calcium levels but raise the risk of...

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Identifiers

PMID: 27339034
DOI: 10.1016/j.tem.2016.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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