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Article

FOXA1 is essential for aryl hydrocarbon receptor-dependent regulation of cyclin G2.

Molecular cancer research : MCR - 1 May 2012

Ahmed Shaimaa, Al-Saigh Sarra, Matthews Jason

Abstract excerpt

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Recently, AHR has emerged as a potential therapeutic target for breast cancer by virtue of its ability to modulate estrogen receptor-α (ERα) signalling and/or its ability to block cell proliferation. Our previous studies identified...

Read the complete abstract on PubMed

Topics

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Share to Breast Neoplasms
Share to Cell Line, Tumor
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Hepatocyte Nuclear Factor 3-alpha

Share to Polychlorinated Dibenzodioxins

Share to Receptors, Aryl Hydrocarbon

Share to RNA, Small Interfering

Source

Identifiers

PMID: 22596188
DOI: 10.1158/1541-7786.MCR-11-0502

Genes

AHR
CCNG2
FOXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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