Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes.

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Article

Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes.

Blood - 15 Mar 1992

Stewart G W, Hepworth-Jones B E, Keen J N, Dash B C, Argent A C, Casimir C M

Abstract excerpt

Human red blood cells (RBCs) that are deficient in an integral membrane-associated protein ("stomatin") of apparent molecular mass 31 Kd show a catastrophic increase in passive membrane permeability to the univalent cations Na+ and K+ and are stomatocytic in shape. We have purified this protein f...

Topics

Amino Acid Sequence
Base Sequence
Biological Transport
Blood Proteins
DNA
Erythrocyte Membrane
Erythrocytes, Abnormal
Humans
Membrane Proteins
Molecular Sequence Data
Mutation
Potassium
RNA, Messenger
Sodium

Source

Open in PubMed

Identifiers

PMID: 1547348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1547348-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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