Article
Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells.
Cell death & disease - 6 Sept 2018
Enane Francis O, Saunthararajah Yogen, Korc Murray
Abstract excerpt
Chemotherapeutic drugs have a common intent to activate apoptosis in tumor cells. However, master regulators of apoptosis (e.g., p53, p16/CDKN2A) are frequently genetically inactivated in cancers, resulting in multidrug resistance. An alternative, p53-independent method for terminating malignant proliferation is to engage terminal-differentiation. Normally, the exponential proliferation of lineage-committed...
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