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Article

p53 balances between tissue hierarchy and anarchy

24 Mar 2019

Abstract excerpt

Normal tissues are organized in a hierarchical model, whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies, leading to normal development and homeostasis. Alike, tumors are organized in a hierarchical manner, with cancer SCs residing at the apex, contributing to the development and nourishment of tumors. p53, the well-known...

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PMID: 30925590
DOI: 10.1093/jmcb/mjz022

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