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Article

Lamin A and microtubules collaborate to maintain nuclear morphology.

Nucleus (Austin, Tex.) - 4 Jul 2017

Tariq Zeshan, Zhang Haoyue, Chia-Liu Alexander, Shen Yang, Gete Yantenew, Xiong Zheng-Mei, Tocheny Claire, Campanello Leonard, Wu Di, Losert Wolfgang, Cao Kan

Abstract excerpt

Lamin A (LA) is a critical structural component of the nuclear lamina. Mutations within the LA gene (LMNA) lead to several human disorders, most striking of which is Hutchinson-Gilford Progeria Syndrome (HGPS), a premature aging disorder. HGPS cells are best characterized by an abnormal nuclear morphology known as nuclear blebbing, which arises due to the accumulation of progerin, a dominant mutant form of LA....

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Identifiers

PMID: 28557611
DOI: 10.1080/19491034.2017.1320460
PMCID: PMC5597299

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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