Article
Increased plasticity of the nuclear envelope and hypermobility of telomeres due to the loss of A-type lamins.
Biochimica et biophysica acta - 1 Apr 2010
De Vos Winnok H, Houben Frederik, Hoebe Ron A, Hennekam Raoul, van Engelen Baziel, Manders Erik M M, Ramaekers Frans C S, Broers Jos L V, Van Oostveldt Patrick
Abstract excerpt
BACKGROUND: The nuclear lamina provides structural support to the nucleus and has a central role in defining nuclear organization. Defects in its filamentous constituents, the lamins, lead to a class of diseases collectively referred to as laminopathies. On the cellular level, lamin mutations aff...
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