Article
Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach.
European archives of psychiatry and clinical neuroscience - 1 Apr 2018
Abdulkadir Mohamed, Londono Douglas, Gordon Derek, Fernandez Thomas V, Brown Lawrence W, Cheon Keun-Ah, Coffey Barbara J, Elzerman Lonneke, Fremer Carolin, Fründt Odette, Garcia-Delgar Blanca, Gilbert Donald L, Grice Dorothy E, Hedderly Tammy, Heyman Isobel, Hong Hyun Ju, Huyser Chaim, Ibanez-Gomez Laura, Jakubovski Ewgeni, Kim Young Key, Kim Young Shin, Koh Yun-Joo, Kook Sodahm, Kuperman Samuel, Leventhal Bennett, Ludolph Andrea G, Madruga-Garrido Marcos, Maras Athanasios, Mir Pablo, Morer Astrid, Müller-Vahl Kirsten, Münchau Alexander, Murphy Tara L, Plessen Kerstin J, Roessner Veit, Shin Eun-Young, Song Dong-Ho, Song Jungeun, Tübing Jennifer, van den Ban Els, Visscher Frank, Wanderer Sina, Woods Martin, Zinner Samuel H, King Robert A, Tischfield Jay A, Heiman Gary A, Hoekstra Pieter J, Dietrich Andrea
Abstract excerpt
Genetic studies in Tourette syndrome (TS) are characterized by scattered and poorly replicated findings. We aimed to replicate findings from candidate gene and genome-wide association studies (GWAS). Our cohort included 465 probands with chronic tic disorder (93% TS) and both parents from 412 families (some probands were siblings). We assessed 75 single nucleotide polymorphisms (SNPs) in 465 parent-child trios;...
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