Article
Genome-wide association study of Tourette's syndrome.
Molecular psychiatry - 1 Jun 2013
Scharf J M, Yu D, Mathews C A, Neale B M, Stewart S E, Fagerness J A, Evans P, Gamazon E, Edlund C K, Service S K, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis L K, Han B, Crane J, Moorjani P, Crenshaw A T, Parkin M A, Reus V I, Lowe T L, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath D C, Smit J H, King R A, Fernandez T V, Leckman J F, Kidd K K, Kidd J R, Pakstis A J, State M W, Herrera L D, Romero R, Fournier E, Sandor P, Barr C L, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman C L, Bruun R D, Erenberg G, Naarden A L, Lee P C, Weiss N, Kremeyer B, Berrío G B, Campbell D D, Cardona Silgado J C, Ochoa W C, Mesa Restrepo S C, Muller H, Valencia Duarte A V, Lyon G J, Leppert M, Morgan J, Weiss R, Grados M A, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield J A, Heiman G A, Gilbert D L, Hoekstra P J, Robertson M M, Kurlan R, Liu C, Gibbs J R, Singleton A, Hardy J, Strengman E, Ophoff R A, Wagner M, Moessner R, Mirel D B, Posthuma D, Sabatti C, Eskin E, Conti D V, Knowles J A, Ruiz-Linares A, Rouleau G A, Purcell S, Heutink P, Oostra B A, McMahon W M, Freimer N B, Cox N J, Pauls D L
Abstract excerpt
Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial recurrence rates among neuropsychiatric diseases with complex inheritance. However, the identification of definitive TS susceptibility genes remains elusive. Here, we report the first genome-wide association study (GWAS) of TS in 1285 cases and 4964 ancestry-matched controls of European ancestry, including two...
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