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Article

Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects.

Molecular psychiatry - 1 Mar 2018

Kim Y, Giusti-Rodriguez P, Crowley J J, Bryois J, Nonneman R J, Ryan A K, Quackenbush C R, Iglesias-Ussel M D, Lee P H, Sun W, de Villena F P-M, Sullivan P F

Abstract excerpt

Genome-wide association studies (GWAS) for schizophrenia have identified over 100 loci encoding >500 genes. It is unclear whether any of these genes, other than dopamine receptor D2, are immediately relevant to antipsychotic effects or represent novel antipsychotic targets. We applied an in vivo molecular approach to this question by performing RNA sequencing of brain tissue from mice chronically treated with the...

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PMID: 28555076
DOI: 10.1038/mp.2017.111
PMCID: PMC5709242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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