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Article

MicroRNA-200b is downregulated in colon cancer budding cells

26 May 2017

Abstract excerpt

BACKGROUND: The microRNA-200 (miR-200) family acts as a major suppressor of epithelial-mesenchymal transition (EMT). Impaired miR-200 expression may lead to EMT initiation and eventually cancer dissemination. The presence of tumor budding cells (TBC) is associated with metastasis and poor prognosis, and molecular similarities to EMT indicate that these cells may reflect ongoing EMT. The aim of this study was to...

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PMID: 28552992
DOI: 10.1371/journal.pone.0178564

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