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Article

Tumor cell budding and laminin-5 expression in colorectal carcinoma can be modulated by the tissue micro-environment.

International journal of cancer - 1 Dec 2000

Sordat I, Rousselle P, Chaubert P, Petermann O, Aberdam D, Bosman F T, Sordat B

Abstract excerpt

Expression of laminin-5 alpha3, beta3 and gamma2 protein subunits was investigated in colorectal adenocarcinomas using immunostaining and confocal microscopy. The laminin-5 heterotrimer was found in basement membranes and as extracellular deposits in tumor stroma. In contrast to the alpha3 subunit, which was under-expressed, the gamma2 and beta3 subunits were detected in the cytoplasm of carcinoma cells...

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PMID: 11072238
DOI: 10.1002/1097-0215(20001201)88:5<708::aid-ijc5>3.0.co;2-j

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