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Article

Sequential expression of miR ‐182 and miR ‐503 cooperatively targets FBXW7 , contributing to the malignant transformation of colon adenoma to adenocarcinoma

1 Oct 2014

Abstract excerpt

Genetic changes in colon cancer are known to parallel the tissue abnormalities associated with the disease, namely adenoma and adenocarcinoma. The role of microRNA dysregulation in dysplastic progression, however, is not well understood. Here, we show that miR-182 and miR-503 undergo sequential up-regulation and drive the progression of colon adenoma to adenocarcinoma by cooperatively down-regulating the tumour...

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PMID: 25269767
DOI: 10.1002/path.4407

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