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Article

miR-200c-driven Mesenchymal-To-Epithelial Transition is a Therapeutic Target in Uterine Carcinosarcomas.

Scientific reports - 15 Jun 2017

Tseng Jill H, Bisogna Maria, Hoang Lien N, Olvera Narciso, Rodriguez-Aguayo Cristian, Lopez-Berestein Gabriel, Sood Anil K, Levine Douglas A, Jelinic Petar

Abstract excerpt

Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with poor prognoses and limited treatment options. These tumors are hypothesized to develop from the endometrial adenocarcinoma (EAC) through epithelial-mesenchymal transition (EMT). We test this long-standing hypothesis by depleting miR-200, a family of microRNAs critical for EMT, in EAC cell lines. Our data suggest that UCSs do not...

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Share to Carcinosarcoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Pathologic

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Identifiers

PMID: 28620240
DOI: 10.1038/s41598-017-03972-7
PMCID: PMC5472620

Genes

MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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miR-200c-driven Mesenchymal-To-Epithelial Transition is a Therapeutic Target in Uterine Carcinosarcomas.PMID 28620240Read ↗

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