Article
Molecular profiling of tumour budding implicates TGFβ-mediated epithelial-mesenchymal transition as a therapeutic target in oral squamous cell carcinoma.
The Journal of pathology - 1 Aug 2015
Jensen D H, Dabelsteen E, Specht L, Fiehn A M K, Therkildsen M H, Jønson L, Vikesaa J, Nielsen F C, von Buchwald C
Abstract excerpt
Although tumour budding is an adverse prognostic factor for many cancer types, the molecular mechanisms governing this phenomenon are incompletely understood. Therefore, understanding the molecular basis of tumour budding may provide new therapeutic and diagnostic options. We employ digital image analysis to demonstrate that the number of tumour buds in cytokeratin-stained sections correlates with patients having...
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