Article
An in vitro model of the epithelial airway reveals a key function for EHF in lung homeostasis and disease.
Disease models & mechanisms - 1 Jun 2025
Pinte Laetitia, Vila-Gonzalez Marta, Williams Eleanor C, Causa Erika, Fradique Ricardo, Pauzaite Tekle, Passemar Charlotte, Becca Silvia, Gribben Christopher, Ye Shiqi, Al-Thani Maha, Bachinger Fabian, Roos Floris J M, Nathan James A, Mohorianu Irina, Floto Andres, Cicuta Pietro, Vallier Ludovic
Abstract excerpt
In the lung airways, multiple cell types facilitate airflow to alveoli, clearing out debris, particles and pathogens. These vital processes are impeded in chronic inflammatory respiratory diseases, in which the epithelium typically suffers from inflammation, infections and hypoxia. An increasing body of evidence highlights the critical role of modifier genes in responses and resistance against these pathogenic...
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