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Article

USP7 inhibitors disrupt EBNA1 interactome and EBV tumorigenesis

2024-09-02

Abstract excerpt

Epstein-Barr virus (EBV) is a ubiquitous human ɣ-herpesvirus implicated in various malignancies, including Burkitt’s lymphoma and gastric carcinomas. In most EBV-associated cancers, the viral genome is maintained as an extrachromosomal episome by the EBV nuclear antigen-1 (EBNA1). EBNA1 is considered to be a highly stable protein that interacts with the ubiquitin-specific protease 7 (USP7). Here, we show that phar...

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Literature Corpus work
df5bd457-6a56-5d0e-87ac-5e39aa789745
DOI
10.22541/au.172530081.12484333/v1
Open publication

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USP7 inhibitors disrupt EBNA1 interactome and EBV tumorigenesisDOI 10.22541/au.172530081.12484333/v1
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