Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer

24 Feb 2021

Abstract excerpt

Protein ubiquitination is a critical regulator of cellular homeostasis. Aberrations in the addition or removal of ubiquitin can result in the development of cancer and key components of the ubiquitination machinery serve as oncogenes or tumour suppressors. An emerging target in the development of cancer therapeutics are the deubiquitinase (DUB) enzymes that remove ubiquitin from protein substrates. Whether this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Genetics and Neurodevelopmental Disorders
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33627786
DOI: 10.1038/s41388-021-01679-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancerPMID 33627786Read ↗

Cellular functions, molecular signalings and therapeutic applications: Translational potential of deubiquitylating enzyme USP9X as a drug target in cancer treatmentSemantic proximity Read ↗

USP3 : Key deubiquitylation enzyme in human diseasesSemantic proximity Read ↗

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.Semantic proximity Read ↗

Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesisSemantic proximity Read ↗

The role of USP1 deubiquitinase in the pathogenesis and therapy of cancerSemantic proximity Read ↗

USP12 regulates cell cycle progression by involving c-Myc, cyclin D2 and BMI-1.Semantic proximity Read ↗

USP13: Multiple Functions and Target InhibitionSemantic proximity Read ↗

The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeuticsSemantic proximity Read ↗

Role of Deubiquitinases in Human Cancers: Potential Targeted TherapySemantic proximity Read ↗

Targeting deubiquitinase USP28 for cancer therapySemantic proximity Read ↗

USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell CarcinomaSemantic proximity Read ↗

USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.