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Article

Overexpression of B-cell lymphoma 6 alters gene expression profile in a myeloma cell line and is associated with decreased DNA damage response.

Cancer science - 1 Aug 2017

Tahara Kenichi, Takizawa Makiko, Yamane Arito, Osaki Yohei, Ishizaki Takuma, Mitsui Takeki, Yokohama Akihiko, Saitoh Takayuki, Tsukamoto Norifumi, Matsumoto Morio, Murakami Hirokazu, Nojima Yoshihisa, Handa Hiroshi

Abstract excerpt

B-cell lymphoma 6 (BCL6) attenuates DNA damage response (DDR) through gene repression and facilitates tolerance to genomic instability during immunoglobulin affinity maturation in germinal center (GC) B cells. Although BCL6 expression is repressed through normal differentiation of GC B cells into plasma cells, a recent study showed the ectopic expression of BCL6 in primary multiple myeloma (MM) cells. However,...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Identifiers

PMID: 28544233
DOI: 10.1111/cas.13283
PMCID: PMC5543477

Genes

BCL6
ATM

Provenance

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Overexpression of B-cell lymphoma 6 alters gene expression profile in a myeloma cell line and is associated with decreased DNA damage response.PMID 28544233Read ↗

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KDM6A Regulates Immune Response Genes in Multiple MyelomaSemantic proximity Read ↗

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