Article

KDM6A Regulates Immune Response Genes in Multiple Myeloma

2024-02-12

Abstract excerpt

The histone H3K27 demethylase KDM6A is a tumor suppressor in multiple cancers, including multiple myeloma (MM). We created isogenic MM cells disrupted for KDM6A and tagged the endogenous protein to facilitate genome wide studies. KDM6A binds genes associated with immune recognition and cytokine signaling. Most importantly, KDM6A binds and activates NLRC5 and CIITA encoding regulators of Major Histocompatibility...

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Literature Corpus work: 7354c3c1-c7f2-5536-9463-325acb2812e3
DOI: 10.1101/2024.02.12.579179

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