Article
Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma.
Leukemia - 1 Nov 2007
Iqbal J, Greiner T C, Patel K, Dave B J, Smith L, Ji J, Wright G, Sanger W G, Pickering D L, Jain S, Horsman D E, Shen Y, Fu K, Weisenburger D D, Hans C P, Campo E, Gascoyne R D, Rosenwald A, Jaffe E S, Delabie J, Rimsza L, Ott G, Müller-Hermelink H K, Connors J M, Vose J M, McKeithan T, Staudt L M, Chan W C
Abstract excerpt
Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed biologically and prognostically distinct subgroups: germinal center B-cell-like (GCB), activated B-cell-like (ABC) and primary mediastinal (PM) DLBCL. The BCL6 gene is often translocated and/or mutated in DLBCL. Therefore, we examined the BCL6 molecular alterations in these DLBCL subgroups, and their impact on BCL6 expression and BCL6...
Topics
- DNA Mutational Analysis
- DNA-Binding Proteins
- Exons
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- In Situ Hybridization, Fluorescence
- Introns