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KDM6A regulates immune response genes in multiple myeloma

24 Jul 2024

Abstract excerpt

ABSTRACT: The histone H3 at lysine 27 (H3K27) demethylase lysine demethylase 6A (KDM6A) is a tumor suppressor in multiple cancers, including multiple myeloma (MM). We created isogenic MM cells disrupted for KDM6A and tagged the endogenous protein to facilitate genome-wide studies. KDM6A binds genes associated with immune recognition and cytokine signaling. Most importantly, KDM6A binds and activates NLRC5 and...

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Share to Histone Deacetylase Inhibitors Research
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PMID: 39046770
DOI: 10.1182/blood.2024024518

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