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Article

The human asparaginase enzyme (ASPG) inhibits growth in leukemic cells

24 May 2017

Abstract excerpt

The human protein ASPG is an enzyme with a putative antitumor activity. We generated in bacteria and then purified a recombinant GST-ASPG protein that we used to characterize the biochemical and cytotoxic properties of the human ASPG. We demonstrated that ASPG possesses asparaginase and PAF acetylhydrolase activities that depend on a critical threonine residue at position 19. Consistently, ASPG but not its T19A...

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PMID: 28542249
DOI: 10.1371/journal.pone.0178174

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