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Article

Structural and functional alterations of FLT3 in acute myeloid leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2009

Meshinchi Soheil, Appelbaum Frederick R

Abstract excerpt

Hematopoiesis is highly regulated through cytokine-induced stimulation of multiple signal transduction pathways in order to mediate appropriate differentiation and proliferation of specific progenitor populations. Ligand-induced stimulation of the FMS-like tyrosine kinase 3 (FLT3) leads to activation of multiple downstream effector pathways resulting in differentiation and proliferation of specific progenitor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 19549778
DOI: 10.1158/1078-0432.CCR-08-1123
PMCID: PMC2716016

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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